Histoacryl® Flexible Pack

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Histoacryl® Flexible Pack

The Advanced Choice for Skin Closure

Tissue Adhesive
Histoacryl® Flexible clear and blue
Tissue Adhesive
Histoacryl® Flexible blue
Tissue adhesive
Histoacryl® Flexible blue handling
Tissue Adhesive
Histoacryl® Flexible clear
Tissue Adhesive
Histoacryl® Flexible clear handling
Tissue Adhesive
Histoacryl® Flexible clear and blue
Tissue Adhesive
Histoacryl® Flexible blue
Tissue adhesive
Histoacryl® Flexible blue handling
Tissue Adhesive
Histoacryl® Flexible clear
Tissue Adhesive
Histoacryl® Flexible clear handling

Histoacryl® Flexible is a sterile and liquid topical skin adhesive, consisting of n-butyl-2 cyanoacrylate and a softener to enhance flexibility.

 Its advanced formulation supports the closure of short and long incisions of up to 25 cm[1-3], making it suitable for use in a broad range of surgical procedures as well as in emergency care settings.

It’s available in 2 versions:

  • Blue version: For easy visual assessment of the layer that has been applied
  • Clear Version: Specially designed for facial and cosmetic applications

 Histoacryl® Flexible may be used with an optional applicator tip intended to provide easy distribution of the adhesive over the wound, ensuring a precise & comfortable application.

Advantages

High patient satisfaction

  • Less pain than suture materials in skin closure. [4]
  • Patient recovery time after wound closure is shorter than with subcuticular sutures. [4]
  • No removal visit required: spontaneously detached between 4-8 days after application. [5]
  • Showering is allowed. [6]
  • No wound dressing is required. [6]

Saves time

  • Decreased skin closure time compared to sutures. [5,6]

 Microbial barrier

  • In vitro studies have shown that Histoacryl acts as a physical microbial barrier during 7 days for the following bacteria: [7,8]
    Staphylococcus aureus, Staphylococcus epidermis, Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecium, Brevundimonas diminuta, Candida albicans

 Safe and efficient polymerization

  • 30 seconds polymerization. [5]
  • Only the application of a single layer of adhesive is required. [6]
  • During the polymerization the temperature increase is around of 4 ºC (from 37 ºC to 41.4 ºC) [9]

 Ready to use

  • Storable at 25ºC [9]
  • No polymerization in the tip nor in the ampoule once the product is opened​.

Indication

Histoacryl® Flexible is indicated for the closure of minimum-tension skin wounds from clean surgical incisions and simple, thoroughly cleansed, trauma induced lacerations.

In case there was tension along the wound line, ensure minimizing the tension by approximating wound edges (e.g. using subcuticular sutures) before applying Histoacryl® Flexible to the skin surface.

[1] RDR/DID/CHM/DCE/16106 – Validation of Histoacryl® Flexible_in vivo study

[2] Report ECT / Dr. Gabriel Siedle / Test of the flexibility of Histoacryl® and Histoacryl® Flexible, November 2012

[3] Frey-Tox Report / Lab.- Nr. 03145 / Flexible Gewebekleber

[4] Dasrilsyah RA, Kalok A, Ng BK, Ali A, Teik Chew K, Lim PS. Perineal skin tear repair following vaginal birth; skin adhesive versus conventional suture - a randomised controlled trial. J Obstet Gynaecol. 2021;41(2):242-247. 

[5] Histoacryl® Flexible Instructions for Use

[6] Witting S, Ingwersen M, Lehmann T, Aschenbach R, Eckardt N, Jürgen Zanow, et al. Wound Closure After Port Implantation-A Randomized Controlled Trial Comparing Tissue Adhesive and Intracutaneous Suturing. Dtsch Arztebl Int. 2021;118(44):749-55.

[7] Internal Report_MDT medical device testing GmbH report / Project 12m020 / Determination of Microbiological Barrier Properties of Two Topical Skin Adhesives